Paraquat Induces Apoptosis through Cytochrome C Release and ERK Activation
Biomolecules & Therapeutics
; : 503-509, 2014.
Article
en En
| WPRIM
| ID: wpr-16136
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WPRO
ABSTRACT
Paraquat has been suggested to induce apoptosis by generation of reactive oxygen species (ROS). However, little is known about the mechanism of paraquat-induced apoptosis. Here, we demonstrate that extracellular signal-regulated protein kinase (ERK) is required for paraquat-induced apoptosis in NIH3T3 cells. Paraquat treatment resulted in activation of ERK, and U0126, inhibitors of the MEK/ERK signaling pathway, prevented apoptosis. Moreover, paraquat-induced apoptosis was associated with cytochrome C release, which could be prevented by treatment with the MEK inhibitors. Taken together, our findings suggest that ERK activation plays an active role in mediating paraquat-induced apoptosis of NIH3T3 cells.
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Asunto principal:
Paraquat
/
Proteínas Quinasas
/
Negociación
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Especies Reactivas de Oxígeno
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Apoptosis
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Citocromos c
Idioma:
En
Revista:
Biomolecules & Therapeutics
Año:
2014
Tipo del documento:
Article