Effects of IL-7 on human lymphocytes
Journal of Korean Medical Science
;
: 93-98, 1993.
Artículo
en Inglés
| WPRIM
| ID: wpr-161580
ABSTRACT
Interleukin-7 (IL-7) is known as a growth factor for pre B-cell and mature T-cells in human. But in leukemic cells, IL-7 effect is variously reported. To investigate the effect of IL-7 on the cells of childhood acute leukemia we used 3H-Thymidine assay. Twelve Acute lymphoblastic leukemia (ALL), seven T-ALL and three Acute myelogenous leukemia (AML) were involved in this study. Two out of twelve ALL and three out of seven T-ALL bone marrow (BM) cells were stimulated by IL-7 in 3H-Thymidine incorporation. In normal and AML BM cells, IL-7 had no stimulatory activity as in various leukemic cell lines. Two normal peripheral blood T-cells responded to IL-7 dose dependently. We have seen the effect of IL-7 to stimulate T-lineage cells but, for precise conclusion, further study using more purified samples will be needed.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Células Tumorales Cultivadas
/
Linfocitos
/
Leucemia-Linfoma de Células T del Adulto
/
Leucemia Mieloide Aguda
/
Interleucina-4
/
Interleucina-7
/
Relación Dosis-Respuesta a Droga
/
Leucemia-Linfoma Linfoblástico de Células Precursoras
Límite:
Adolescente
/
Niño
/
Child, preschool
/
Femenino
/
Humanos
/
Lactante
/
Masculino
Idioma:
Inglés
Revista:
Journal of Korean Medical Science
Año:
1993
Tipo del documento:
Artículo
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