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A comparison of 24- vs. 48-week peginterferon plus ribavirin in patients with genotype 1 chronic hepatitis C / 대한간학회지
The Korean Journal of Hepatology ; : 496-503, 2009.
Artículo en Coreano | WPRIM | ID: wpr-161890
ABSTRACT
BACKGROUND/

AIMS:

The standard therapy for patients with genotype 1 chronic hepatitis C (CHC) is a combination of peginterferon and ribavirin for 48 weeks. However, the most appropriate duration of treatment remains to be established because of treatment-related side effects and cost. The aim of this study was to compare the efficacies of 24- and 48-week treatments, and to assess the efficacy of split 24-week therapy (a further 24 weeks of treatment in patients with relapse after the initial 24 weeks of treatment).

METHODS:

A total of 130 patients with genotype 1 CHC was treated between June 2004 and December 2006. Patients with undetectable HCV RNA at 24 weeks of treatment (as assessed by qualitative PCR assay; n=101 patients) were allowed to choose either 24 or 48 weeks as the duration of their treatment; 51 patients chose the 24-week treatment regimen and the remainder chose the 48-week regimen. Patients who relapsed after 24 weeks of treatment were treated for further 24 weeks. The sustained virologic response (SVR) of each treatment group was analyzed.

RESULTS:

The SVR rate was higher in patients treated for 48 weeks than in those treated for 24 weeks (74.0% vs. 52.9%, P=0.028). In the multivariate analysis, age or = 150,000/mm3, and treatment duration for 48 weeks remained significant independent predictors of SVR. Fourteen of the 24 patients who relapsed in the 24-week treatment group received split 24-week therapy, and 6 patients (42.9%) achieved SVR. The overall SVR rate did not differ significantly between the 24-week treatment group, including those who underwent 24-week split therapy (64.7%), and the 48-week treatment group (64.7% vs. 74%, P=0.311).

CONCLUSIONS:

The 24-week plus additional split 24-week therapy following failure is a useful treatment strategy for patients with genotype 1 CHC.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Antivirales / Polietilenglicoles / Ribavirina / ARN Viral / Esquema de Medicación / Análisis Multivariante / Factores de Edad / Hepacivirus / Hepatitis C Crónica / Quimioterapia Combinada Tipo de estudio: Estudio pronóstico / Investigación cualitativa Límite: Adulto / Anciano / Femenino / Humanos / Masculino Idioma: Coreano Revista: The Korean Journal of Hepatology Año: 2009 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Antivirales / Polietilenglicoles / Ribavirina / ARN Viral / Esquema de Medicación / Análisis Multivariante / Factores de Edad / Hepacivirus / Hepatitis C Crónica / Quimioterapia Combinada Tipo de estudio: Estudio pronóstico / Investigación cualitativa Límite: Adulto / Anciano / Femenino / Humanos / Masculino Idioma: Coreano Revista: The Korean Journal of Hepatology Año: 2009 Tipo del documento: Artículo