Acute Renal Failure after Hematopoietic Cell Transplantation : Cause and Prognosis / 대한신장학회잡지
Korean Journal of Nephrology
;
: 443-449, 2002.
Artículo
en Coreano
| WPRIM
| ID: wpr-162512
ABSTRACT
BACKGROUND:
Common complications after hematopoietic stem cell transplantation(HCT) include sepsis, graft versus host disease(GVHD), veno-occlusive disease(VOD), drug-induced nephrotoxicity, and acute renal failure(ARF). Prior studies report that the presence of ARF affects prognosis. However, we are unaware of such reports on the incidence of ARF after HCT in Koreans, and whether or not the development of ARF is related to prognosis. The purpose of our study was to investigate the cause of ARF after HCT and its relation to prognosis.METHODS:
163 patients received HCT at Seoul National University Hospital since 1985, of which, 107 were available for review.RESULTS:
ARF after HCT developed in 52 patients (48.6%). In the three clinical causes, VOD, sepsis, and GVHD, risk factor related to the development of ARF was preexisting VOD. Logistic regression confirmed this association(odds ratio 4.4). The causes of ARF were different according to the periods it developed, and cyclosporin nephrotoxicity was the main cause through the whole period after HCT. The overall survival was worse in the ARF group(60 vs 73 %; p < 0.05). ARF group was split into two groups patients whose peak serum creatinine levels were below 3.0 mg/dL(mild ARF group) and those who were above 3.0 mg/dL(severe ARF group). Severe ARF group had worse survival than mild ARF group and patients without ARF(p < 0.01).CONCLUSION:
VOD, sepsis, GVHD after HCT increase the risk of the deveolopment of ARF, but cyclosprin nephrotoxicity is the main cause of ARF. Severe ARF is a factor influencing the prognosis of patients who received HCT.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Pronóstico
/
Células Madre Hematopoyéticas
/
Modelos Logísticos
/
Incidencia
/
Factores de Riesgo
/
Ciclosporina
/
Trasplante de Células
/
Sepsis
/
Trasplante de Células Madre Hematopoyéticas
/
Trasplantes
Tipo de estudio:
Estudio de etiología
/
Estudio de incidencia
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Humanos
País/Región como asunto:
Asia
Idioma:
Coreano
Revista:
Korean Journal of Nephrology
Año:
2002
Tipo del documento:
Artículo
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