Frequently Relapsing Secondary Cutaneous Diffuse Large B-cell Lymphoma in the Skin / 대한피부과학회지

ABSTRACT

We report a case of cutaneous diffuse large B cell lymphoma in a 66-year-old male who had a 5-year history of diffuse large B cell lymphoma on the left inguinal lymph node. The patient visited our clinic for the first time for relief of a non-tender well-defined erythematous hard nodules on the left foot and left thigh that had been present form 6 months and 1 month, respectively. Histologic examination revealed diffuse dense infiltration of large neoplastic lymphocytes with scanty cytoplasm and large nuclei. They showed a positive reaction to CD20 and CD79a, suggesting a B cell lineage. The patient was diagnosed with secondary cutaneous diffuse large B cell lymphoma. After 1 month of radiation therapy, complete remission was achieved. Five and seven months later, the patient returned foe relief of non-tender red-to-brown hard nodules on the left and right thigh, respectively. Histologic examination and immunohistochemical stain prompted the same diagnosis as previously. After radiotherapy and chemotherapy, the skin lesion was nearly resolved, and no evidence of extracutaneous involvement has been noted since.