Does Epidural Clonidine Decrease the Sevoflurane Concentration for Maintaining the BIS 50? / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 60-65, 2006.
Artículo
en Coreano
| WPRIM
| ID: wpr-162979
ABSTRACT
BACKGROUND:
The aim of this study was to investigate the influence of epidural clonidine on the BIS, and its potential dose-sparing effect on the sevoflurane requirement for maintaining the BIS 50.METHODS:
Forty ASA I or II patients aged 20 to 65, undergoing lower abdominal, gynecologic surgery under general anesthesia, were randomly allocated to either a 10 ml epidural normal saline injection group (n = 20) or a 10 ml epidural clonidine 3microgram/kg mixed with normal saline injection group (n = 20). They received 5 mg/kg thiopental sodium and 0.1 mg/kg vecuronium bromide for induction, with no premedication. After surgical incision, the sevoflurane concentration was controlled to maintain the BIS 50. Epidural saline or clonidine was then injected and end-tidal sevoflurane concentration to maintain the BIS 50, the heart rate (HR) and mean arterial pressure (MBP) were measured every 5 min over a 20 minute period.RESULTS:
The end-tidal sevoflurane concentration in the clonidine group decreased by 27.5% after the epidural clonidine injection (1.49 +/- 0.23 vol% vs. 1.08 +/- 0.27 vol%; P0.05). There were no changes in the heart rate and mean blood pressure in either group.CONCLUSIONS:
Epidural clonidine causes a significant decrease in the BIS, and lowers the end-tidal sevoflurane concentration required for maintaining the BIS 50.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Premedicación
/
Procedimientos Quirúrgicos Ginecológicos
/
Tiopental
/
Presión Sanguínea
/
Bromuro de Vecuronio
/
Clonidina
/
Presión Arterial
/
Frecuencia Cardíaca
/
Anestesia General
Límite:
Femenino
/
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Anesthesiology
Año:
2006
Tipo del documento:
Artículo
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