Assessing the Effect of Finasteride by Prostate Tissue Composition / 대한비뇨기과학회지

ABSTRACT

PURPOSE: We determine whether the epithelial content of the prostate and prostate volume before treatment related to the effect of finasteride. MATERIALS AND METHODS: Transrectal ultrasonography (TRUS) guided sextant biopsies of the prostate were obtained from 30 male subjects with symptomatic benign prostatic hyperplasia (BPH) prior to initiating therapy with finasteride. Anti-cytokeratine staining and computer-assisted quantitative color image analysis were utilized to quantify the area density of glandular epithelium, stroma and glandular lumen. The clinical response to finasteride was based upon changes in peak urinary flow rate (Qmax), post voiding residual urine (PVR), International Prostate Symptom Score (IPSS), serum prostate specific antigen (PSA) and prostate volume. RESULTS: The average compositions among the 30 glands were as the following: epithelium 15.46.3%; stroma 75.3+/-8.6%; lumen 9.3+/-4.5%. The mean prostate volume was 52.0+/-25.3cc. Pretreatment epithelial content and pretreatment prostate volume had no relation with finasteride effect in Qmax, PVR, IPSS and PSA except in change of prostate volume. We found a linear correlation between pretreatment epithelial volume and finasteride-induced prostate volume reduction (p<0.01). CONCLUSIONS: Finasteride-induced prostate volume reduction has a correlation with pretreatment epithelial volume.