Insulin-like growth factor (IGF)-I and IGF binding proteins axis in diabetes mellitus
Annals of Pediatric Endocrinology & Metabolism
;
: 69-73, 2015.
Artículo
en Inglés
| WPRIM
| ID: wpr-163415
ABSTRACT
Increasing evidence suggests an important role of the insulin-like growth factor (IGF)-IGF binding protein (IGFBP) axis in the maintenance of normal glucose and lipid metabolism. Significant changes occur in the local IGF-I-IGFBPs environment in response to the diabetic milieu. A significant reduction of serum IGF-I levels was observed in patients with type 1 diabetes mellitus (T1DM). Inversely, considerably increased serum levels of IGF-I and IGFBP-3 levels were detected in individuals with glucose intolerance including T2DM. Recently, several prospective studies indicated that baseline levels of IGF-I and IGFBPs are associated with the development of diabetes. These findings suggest that disturbances in insulin and IGF-I-IGFBP axis can affect the development of glucose intolerance including diabetes.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Vértebra Cervical Axis
/
Factor I del Crecimiento Similar a la Insulina
/
Proteínas Portadoras
/
Intolerancia a la Glucosa
/
Proteínas de Unión a Factor de Crecimiento Similar a la Insulina
/
Proteína 1 de Unión a Factor de Crecimiento Similar a la Insulina
/
Proteína 3 de Unión a Factor de Crecimiento Similar a la Insulina
/
Diabetes Mellitus
/
Diabetes Mellitus Tipo 1
/
Metabolismo de los Lípidos
Tipo de estudio:
Estudio observacional
Límite:
Humanos
Idioma:
Inglés
Revista:
Annals of Pediatric Endocrinology & Metabolism
Año:
2015
Tipo del documento:
Artículo
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