Association Study of -2548A/G Polymorphism of Leptin Gene with Antipsychotics-Induced Weight Gain / 대한정신약물학회지
Korean Journal of Psychopharmacology
;
: 423-428, 2006.
Artículo
en Coreano
| WPRIM
| ID: wpr-163637
ABSTRACT
OBJECTIVES:
Leptin, the product of ob gene, is secreted by adipocytes and signals the size of peripheral fat stores to the brain. Several evidences indicate that a polymorphism in the promoter region (-2548A/G) of leptin gene is associated with antipsychotics-induced weight gain. This study aims at investigating the association between the -2548A/G polymorphism of leptin gene and antipsychotics-induced weight gain in Korean schizophrenia patients.METHODS:
Seventy one patients with schizophrenia were recruited. All of the subjects were antipsychotics-naive or free of antipsychotic drugs for the previous 3 months. Genotyping was done for the -2548A/G polymorphism of leptin gene. Body mass index (BMI) was measured at baseline, after 4 weeks and after 8 weeks of antipsychotic drug treatment. The subjects were grouped on the basis of the presence or absence of the G allele (AA vs. AG/GG) and two-sided t tests for independent samples was used to analyze the relationship between two genotype groups and BMI change. And a chi-square analysis was conducted to test the association between the allele type and BMI change.RESULTS:
We could not find any association between the -2548A/G polymorphism of leptin gene and antipsychotics-induced weight gain.CONCLUSION:
Our data do not support the involvement of the -2548A/G polymorphism of leptin gene in antipsychotics-induced weight gain in the acute treatment phase.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Esquizofrenia
/
Antipsicóticos
/
Encéfalo
/
Aumento de Peso
/
Índice de Masa Corporal
/
Regiones Promotoras Genéticas
/
Adipocitos
/
Leptina
/
Alelos
/
Genotipo
Límite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Psychopharmacology
Año:
2006
Tipo del documento:
Artículo
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