A Pilot Study on Total Plasma Homocysteine Level of Patients with Cerebral Infarction
Journal of the Korean Neurological Association
;
: 26-31, 1999.
Artículo
en Coreano
| WPRIM
| ID: wpr-163886
ABSTRACT
BACKGROUND:
Hyperhomocysteinemia has been known to be associated with cerebrovascular disease. It is toxic to vascular endothelial cell and promotes arteriosclerotic detachment. There was no study of the homocysteine level in ischemic stroke patients in Korea except case report. Therefore we measured total plasma homocysteine level in ischemic stroke patients and evaluated association with other stroke risk factors.METHODS:
We measured total plasma homocysteine level in 44 patients with ischemic stroke and 16 age-matched normal controls, and analyzed its relationship to other stroke risk factors. Total plasma homocysteine level was determined by using a radioenzymatic method.RESULTS:
Total plasma homocysteine level was 12.12 5.11 micromol/L in patients and 9.40 1.93 micromol/L in controls. It was 13.03 5.78 micromol/L in lacunar infarction and 9.96 1.57 micromol/L in territory infarction. The total plasma homocysteine level of the patients with hypertension, DM, hyperlipidemia, heart disease, smoking, alcohol, previous stroke, carotid bruit was not different statistically from those without them.CONCLUSIONS:
Total plasma homocysteine level was significantly higher in the ischemic stroke patients than that of controls. Lacunar infarction showed significantly higher level of total plasma homocysteine compared to territory infarction.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Plasma
/
Humo
/
Fumar
/
Infarto Cerebral
/
Proyectos Piloto
/
Factores de Riesgo
/
Hiperhomocisteinemia
/
Accidente Cerebrovascular
/
Células Endoteliales
/
Accidente Vascular Cerebral Lacunar
Tipo de estudio:
Estudio de etiología
/
Factores de riesgo
Límite:
Humanos
País/Región como asunto:
Asia
Idioma:
Coreano
Revista:
Journal of the Korean Neurological Association
Año:
1999
Tipo del documento:
Artículo
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