Can Fecal Calprotectin Level Be Used as a Markers of Inflammation in the Diagnosis and Follow-Up of Cow's Milk Protein Allergy?
Allergy, Asthma & Immunology Research
;
: 33-38, 2014.
Artículo
en Inglés
| WPRIM
| ID: wpr-164123
ABSTRACT
PURPOSE:
Calprotectin is a cytosolic protein with immunomodulatory, antimicrobial, and antiproliferative actions. The concentration of calprotectin increases in infection, inflammation, and malignancy. We determined if calprotectin can be used as a marker for the diagnosis and follow-up of bowel inflammation in cow's milk protein allergy (CMPA).METHODS:
In total, 32 patients newly diagnosed with CMPA were included (24 IgE-mediated, 8 non-IgE-mediated). In all subjects, a complete blood count, total IgE, cow's milk-specific IgE, and fecal calprotectin (FC) were assessed before and after a cow's milk protein (CMP) elimination diet was started. The results were compared with those of 39 healthy children.RESULTS:
The mean FC value before the CMP elimination diet was 516+/-311 microg/g in the 32 patients with CMPA and 296+/-94 microg/g in the control group (P=0.011). The mean FC value after the diet in these patients was 254+/-169 microg/g, which was significantly different from the mean value before the CMP elimination diet (P<0.001). When we compared FC levels before the CMP elimination diet in the IgE-mediated group with the control group, we found no significant statistical difference (P=0.142). The mean FC value before the CMP elimination diet was 886+/-278 microg/g in the non-IgE-mediated group and 296+/-94 microg/g in the control group; this difference was statistically significant (P<0.001). In the IgE-mediated and non-IgE-mediated groups, FC values after CMP elimination diet were 218+/-90 microg/g and 359+/-288 microg/g, respectively, and FC values before CMP elimination diet were 392+/-209 microg/g and 886+/-278 microg/g, respectively; these differences were statistically significant (P=0.001 and P=0.025, respectively).CONCLUSIONS:
FC levels may be a useful marker for follow-up treatment and recurrence determination in CMPA.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Recurrencia
/
Recuento de Células Sanguíneas
/
Inmunoglobulina E
/
Estudios de Seguimiento
/
Hipersensibilidad a la Leche
/
Citosol
/
Complejo de Antígeno L1 de Leucocito
/
Leche
/
Diagnóstico
/
Dieta
Tipo de estudio:
Estudio diagnóstico
/
Estudio observacional
/
Estudio pronóstico
Límite:
Niño
/
Humanos
Idioma:
Inglés
Revista:
Allergy, Asthma & Immunology Research
Año:
2014
Tipo del documento:
Artículo
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