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Clinical Features of Drug-induced Liver Injury According to Etiology
Journal of Korean Medical Science ; : 1815-1820, 2015.
Artículo en Inglés | WPRIM | ID: wpr-164153
ABSTRACT
Drug-induced liver injury (DILI) is an increasingly common cause of acute hepatitis. We examined clinical features and types of liver injury of 65 affected patients who underwent liver biopsy according DILI etiology. The major causes of DILI were the use of herbal medications (43.2%), prescribed medications (21.6%), and traditional therapeutic preparations and dietary supplements (35%). DILI from herbal medications, traditional therapeutic preparations, and dietary supplements was associated with higher elevations in aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels than was DILI from prescription medications. The types of liver injury based on the R ratio were hepatocellular (67.7%), mixed (10.8%), and cholestatic (21.5%). Herbal medications and traditional therapeutic preparations were more commonly associated with hepatocellular liver injury than were prescription medications (P = 0.002). Herbal medications and traditional therapeutic preparations induce more hepatocellular DILI and increased elevations in AST and ALT than prescribed medications.
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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Aspartato Aminotransferasas / Estudios Retrospectivos / Suplementos Dietéticos / Preparaciones de Plantas / Alanina Transaminasa / Medicamentos bajo Prescripción / Enfermedad Hepática Inducida por Sustancias y Drogas / República de Corea / Fitoterapia Tipo de estudio: Estudio de etiología / Estudio observacional Límite: Adulto / Femenino / Humanos / Masculino País/Región como asunto: Asia Idioma: Inglés Revista: Journal of Korean Medical Science Año: 2015 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Aspartato Aminotransferasas / Estudios Retrospectivos / Suplementos Dietéticos / Preparaciones de Plantas / Alanina Transaminasa / Medicamentos bajo Prescripción / Enfermedad Hepática Inducida por Sustancias y Drogas / República de Corea / Fitoterapia Tipo de estudio: Estudio de etiología / Estudio observacional Límite: Adulto / Femenino / Humanos / Masculino País/Región como asunto: Asia Idioma: Inglés Revista: Journal of Korean Medical Science Año: 2015 Tipo del documento: Artículo