A Rare Case of Acute Lymphoblastic Leukemia with t(12;17)(p13;q21) / 대한진단검사의학회지
The Korean Journal of Laboratory Medicine
;
: 239-243, 2010.
Artículo
en Inglés
| WPRIM
| ID: wpr-164243
ABSTRACT
Patients with ALL rarely present with t(12;17)(p13;q21) as the primary clonal abnormality; this abnormality is associated with the expression of myeloid antigens. In this study, we have reported presumably the first case of this chromosomal abnormality in Korea, thereby facilitating the delineation of a distinct subtype of ALL. A 57-yr-old woman was referred to our hospital because of pancytopenia. Peripheral blood examination showed 55% blasts. The bone marrow was markedly hypercellular, and about 82.4% of all nucleated cells were blasts. The results of immunophenotyping and cytochemical staining suggested early precursor B-ALL. Cytogenetic analysis of the bone marrow cells showed a complex karyotype, including a reciprocal translocation between the short arm of chromosome 12 and the long arm of chromosome 17, t(12;17)(p13;q21). Data from array comparative genomic hybridization were almost consistent with the cytogenetic findings.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Pancitopenia
/
Translocación Genética
/
Médula Ósea
/
Cromosomas Humanos Par 12
/
Cromosomas Humanos Par 17
/
Inmunofenotipificación
/
Análisis Citogenético
/
Leucemia-Linfoma Linfoblástico de Células Precursoras
/
Cariotipificación
Límite:
Femenino
/
Humanos
Idioma:
Inglés
Revista:
The Korean Journal of Laboratory Medicine
Año:
2010
Tipo del documento:
Artículo
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