The effect of doxycycline on canine hip osteoarthritis: design of a 6-months clinical trial
Journal of Veterinary Science
;
: 239-247, 2009.
Artículo
en Inglés
| WPRIM
| ID: wpr-164461
ABSTRACT
Twenty-five dogs were included in a randomized, double-blind trial to assess the efficacy of doxycycline (DOX) orally administered twice a day at 4 mg/kg/day (n = 12) for the treatment of osteoarthritis of the hip. Chondroitin sulfate (CS; 525 mg/day) was used as a positive control (n = 13). Dogs were re-examined monthly for 6 months after initiation of treatment. The assessment protocol included clinical score, radiographic findings and serum osteoarthritis biomarkers. Dogs treated with DOX showed statistically significant improvements (p < 0.05) in lameness, joint mobility, pain on palpation, weight-bearing and overall score at 2, 6, 4, 4 and 4 months, respectively, after treatment. Biomarker levels of CS-WF6 epitope and hyaluronan were significantly increased and decreased (p < 0.05) at 2 and 3 months after treatment compared to pretreatment. These results showed that DOX had a positive therapeutic effect in dogs with osteoarthritis.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Factores de Tiempo
/
Biomarcadores
/
Osteoartritis de la Cadera
/
Resultado del Tratamiento
/
Doxiciclina
/
Enfermedades de los Perros
/
Ácido Hialurónico
/
Articulaciones
/
Cojera Animal
Tipo de estudio:
Guía de Práctica Clínica
Límite:
Animales
Idioma:
Inglés
Revista:
Journal of Veterinary Science
Año:
2009
Tipo del documento:
Artículo
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