Multiple myeloma and chronic myelogenous leukemia: a case report with literature review
Yonsei Medical Journal
; : 293-300, 1993.
Article
en En
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| ID: wpr-164588
Biblioteca responsable:
WPRO
ABSTRACT
This is the case of a 71 year old male who developed multiple myeloma (MM) and chronic myelogenous leukemia (CML) within a two year period. The patient initially presented with osteolytic lesions of the lumbar spine, and following the initial work-up a diagnosis of multiple myeloma with an IgG kappa paraproteinemia was made and appropriate treatment was given. Two years later the patient developed a progressively worsening leukocytosis which was found to be due to Philadelphia Chromosome (Ph1) positive CML. The occurrence in the same patient of two distinct hematologic malignancies suggests a neoplastic transformation of a pluripotent stem cell. A review of the literature appears to support the existence of a relationship between MM and CML as well as a relationship between MM and the myeloproliferative disorders.
Palabras clave
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Células Madre Hematopoyéticas
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Leucemia Mielógena Crónica BCR-ABL Positiva
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Transformación Celular Neoplásica
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Mieloma Múltiple
Límite:
Aged
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Humans
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Male
Idioma:
En
Revista:
Yonsei Medical Journal
Año:
1993
Tipo del documento:
Article