Neuroprotective Effect of Anthocyanin on Experimental Traumatic Spinal Cord Injury
Journal of Korean Neurosurgical Society
;
: 205-211, 2011.
Artículo
en Inglés
| WPRIM
| ID: wpr-164804
ABSTRACT
OBJECTIVE:
We investigated the neuroprotective effect of anthocyanin, oxygen radical scavenger extracted from raspberries, after traumatic spinal cord injury (SCI) in rats.METHODS:
The animals were divided into two groups the vehicle-treated group (control group, n=20) received an oral administration of normal saline via stomach intubation immediately after SCI, and the anthocyanin-treated group (AT group, n=20) received 400 mg/kg of cyanidin 3-O-beta-glucoside (C3G) in the same way. We compared the neurological functions, superoxide expressions and lesion volumes in two groups.RESULTS:
At 14 days after SCI, the AT group showed significant improvement of the BBB score by 16.7+/-3.4%, platform hang by 40.0+/-9.1% and hind foot bar grab by 30.8+/-8.4% (p<0.05 in all outcomes). The degree of superoxide expression, represented by the ratio of red fluorescence intensity, was significantly lower in the AT group (0.98+/-0.38) than the control group (1.34+/-0.24) (p<0.05). The lesion volume in lesion periphery was 32.1+/-2.4 microL in the control and 24.5+/-2.3 microL in the AT group, respectively (p<0.05), and the motor neuron cell number of the anterior horn in lesion periphery was 8.3+/-5.1 cells/HPF in the control and 13.4+/-6.3 cells/HPF in the AT group, respectively (p<0.05).CONCLUSION:
Anthocyanin seemed to reduce lesion volume and neuronal loss by its antioxidant effect and these resulted in improved functional recovery.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Oxígeno
/
Médula Espinal
/
Traumatismos de la Médula Espinal
/
Estómago
/
Recuento de Células
/
Administración Oral
/
Superóxidos
/
Fármacos Neuroprotectores
/
Fluorescencia
/
Pie
Límite:
Animales
Idioma:
Inglés
Revista:
Journal of Korean Neurosurgical Society
Año:
2011
Tipo del documento:
Artículo
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