Gingko biloba extract (EGb 761) attenuates ischemic brain injury-induced reduction in Ca2+ sensor protein hippocalcin / 한국실험동물학회지
Laboratory Animal Research
;
: 199-204, 2012.
Artículo
en Inglés
| WPRIM
| ID: wpr-164973
ABSTRACT
Gingko biloba extract 761 (EGb 761) protects neuronal cells from ischemic brain injury via a number of neuroprotective mechanisms. Hippocalcin is a calcium sensor protein that regulates intracellular calcium concentrations and apoptotic cell death. We investigated whether EGb 761 regulates hippocalcin expression in cerebral ischemia. Male Sprague-Dawley rats were treated with vehicle or EGb 761 (100 mg/kg) prior to middle cerebral artery occlusion (MCAO), and cerebral cortex tissues were collected 24 h after MCAO. A proteomic approach demonstrated reduction in hippocalcin expression in vehicle-treated animals during MCAO, whereas EGb 761 treatment prevented injury-induced decreases in hippocalcin expression. RT-PCR and Western blot analyses indicated that EGb 761 attenuates injury-induced decrease in hippocalcin. These results suggest that the maintenance of hippocalcin during cerebral ischemia contributes to the neuroprotective role of EGb 761.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Encéfalo
/
Lesiones Encefálicas
/
Extractos Vegetales
/
Corteza Cerebral
/
Isquemia Encefálica
/
Western Blotting
/
Calcio
/
Muerte Celular
/
Ratas Sprague-Dawley
/
Ginkgo biloba
Límite:
Animales
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Laboratory Animal Research
Año:
2012
Tipo del documento:
Artículo
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