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Thyroid autoantibodies and thyroid dysfunction in rheumatoid arthritis / 대한내과학회지
Korean Journal of Medicine ; : 317-323, 2000.
Artículo en Coreano | WPRIM | ID: wpr-165052
ABSTRACT

BACKGROUND:

Autoimmune thyroid diseases have been shown to occur in association with connective tissue disorders. This study was undertaken to elucidate the prevalence of thyroid autoantibodies and thyroid dysfunction in Korean patients with rheumatoid arthritis (RA).

METHODS:

We have compared the prevalence of thyroid autoantibodies in 108 RA patients with 81 age-matched controls. Antimicrosomal antibody (AMA) and antithyroglobulin antibody (ATA) were measured by passive hemagglutinin assay. T3, T4, Free T4, and TSH were measured by chemiluminescence method. Rheumatoid factor was measured by nephelometry. Statistical analysis was performed by chi-square, Fisher's exact test, and Pearson correlation test.

RESULTS:

1) The presence of AMA/ATA in patients with RA was significantly higher (28.7%/26.7% in 108 patients) than that of controls (11.1%/9.9% in 81 controls). The positive rates of AMA/ATA in female patients were also higher (28.9%/28.9% in 97 patients) than those of female controls (15.5%/12.1% in 58 controls). 2) Thirty three (17.6%) of 187 patients with RA had the abnormalities of thyroid function; 14 (7.5%) revealed subclinical hypothyroidism, 5 (2.7%) revealed biochemical primary hypothyroidism, 7 (3.7%) revealed sick euthyroid syndrome, and 7 (3.7%) revealed hyperthyroidism.

CONCLUSION:

These results suggest that autoimmune thyroiditis is highly associated with RA in Korean patients, showing the increased prevalence of thyroid autoantibodies and thyroid dysfunctions.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Artritis Reumatoide / Factor Reumatoide / Autoanticuerpos / Enfermedades de la Tiroides / Glándula Tiroides / Síndromes del Eutiroideo Enfermo / Tiroiditis Autoinmune / Prevalencia / Tejido Conectivo / Luminiscencia Tipo de estudio: Estudio de prevalencia Límite: Femenino / Humanos Idioma: Coreano Revista: Korean Journal of Medicine Año: 2000 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Artritis Reumatoide / Factor Reumatoide / Autoanticuerpos / Enfermedades de la Tiroides / Glándula Tiroides / Síndromes del Eutiroideo Enfermo / Tiroiditis Autoinmune / Prevalencia / Tejido Conectivo / Luminiscencia Tipo de estudio: Estudio de prevalencia Límite: Femenino / Humanos Idioma: Coreano Revista: Korean Journal of Medicine Año: 2000 Tipo del documento: Artículo