A Case Report of Kidney Graft Failure after Duodenal Bypass Surgery / 대한내과학회지
Korean Journal of Medicine
;
: 369-372, 2012.
Artículo
en Coreano
| WPRIM
| ID: wpr-165629
ABSTRACT
The calcineurin inhibitor-immunosuppressant tacrolimus is widely used in patients undergoing kidney transplantation. Although tacrolimus is absorbed from the entire gastrointestinal tract, the duodenum is the primary site of its absorption and metabolism. Therefore, duodenal bypass surgery in a renal transplant recipient can significantly disrupt tacrolimus absorption and metabolism. Here, we report a case of allograft failure that developed after duodenal bypass surgery. The patient was a 41-year-old woman who received a deceased donor kidney transplantation. She underwent a gastrojejunostomy due to a duodenal perforation and pancreatitis after endoscopic retrograde cholangiopancreatography. After the surgery, her blood tacrolimus level decreased gradually, and remained lower than therapeutic target levels, even after the tacrolimus dose was increased from 5 to 12 mg/day. Repetitive rejection developed and the patient suffered allograft failure 3 months after bypass surgery. This case raises the importance of drug absorption in renal transplant recipients undergoing duodenal bypass surgery.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Pancreatitis
/
Rechazo en Psicología
/
Donantes de Tejidos
/
Trasplante Homólogo
/
Derivación Gástrica
/
Colangiopancreatografia Retrógrada Endoscópica
/
Trasplante de Riñón
/
Tacrolimus
/
Calcineurina
/
Trasplantes
Límite:
Adulto
/
Femenino
/
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Medicine
Año:
2012
Tipo del documento:
Artículo
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