Genetic predisposition in nonalcoholic fatty liver disease
Clinical and Molecular Hepatology
;
: 1-12, 2017.
Artículo
en Inglés
| WPRIM
| ID: wpr-165816
ABSTRACT
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease whose prevalence has reached global epidemic proportions. Although the disease is relatively benign in the early stages, when severe clinical forms, including nonalcoholic steatohepatitis (NASH), cirrhosis and even hepatocellular carcinoma, occur, they result in worsening the long-term prognosis. A growing body of evidence indicates that NAFLD develops from a complex process in which many factors, including genetic susceptibility and environmental insults, are involved. In this review, we focused on the genetic component of NAFLD, with special emphasis on the role of genetics in the disease pathogenesis and natural history. Insights into the topic of the genetic susceptibility in lean individuals with NAFLD and the potential use of genetic tests in identifying individuals at risk are also discussed.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Pronóstico
/
Fibrosis
/
Prevalencia
/
Carcinoma Hepatocelular
/
Historia Natural
/
Predisposición Genética a la Enfermedad
/
Enfermedad del Hígado Graso no Alcohólico
/
Genética
/
Hepatopatías
/
Hepatopatías Alcohólicas
Tipo de estudio:
Estudio de prevalencia
/
Estudio pronóstico
Idioma:
Inglés
Revista:
Clinical and Molecular Hepatology
Año:
2017
Tipo del documento:
Artículo
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