Good Response of a Salivary Duct Carcinoma to Androgen Deprivation Therapy / 대한내과학회지
Korean Journal of Medicine
;
: 357-360, 2016.
Artículo
en Coreano
| WPRIM
| ID: wpr-165890
ABSTRACT
Salivary duct carcinoma (SDC) is a rare, aggressive tumor. Androgen deprivation therapy (ADT) has been shown to have beneficial effects on SDC-expressing androgen receptors (ARs). A 69-year-old male with a right neck mass presented to our clinic. Computed tomography (CT) of the neck revealed a mass (6 cm diameter) on the right parotid gland, and enlarged lymph nodes. Examination of a needle biopsy sample identified SDC-expressing ARs. We performed total parotidectomy with bilateral neck dissection and concurrent postoperative chemoradiotherapy (total 66 Gy) with cisplatin (35 mg/m2), followed by another two cycles of chemotherapy (cisplatin 60 mg/m2, 5 FU 750 mg/m2). Post-treatment neck CT indicated that no residual tumor tissue remained; however, chest CT indicated recurrence in the right axilla. We initiated ADT with bicalutamide and leuprolide. Five months later, the axillar tumor tissue had almost disappeared. Our case demonstrates that ADT is effective for SDC of ARs. Therefore, clinicians should consider ADT in recurrent or metastatic SDC of ARs.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Glándula Parótida
/
Disección del Cuello
/
Recurrencia
/
Axila
/
Biopsia con Aguja
/
Neoplasias de las Glándulas Salivales
/
Receptores Androgénicos
/
Tomografía Computarizada por Rayos X
/
Cisplatino
/
Leuprolida
Límite:
Anciano
/
Humanos
/
Masculino
Idioma:
Coreano
Revista:
Korean Journal of Medicine
Año:
2016
Tipo del documento:
Artículo
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