β-Adrenergic Receptor and Insulin Resistance in the Heart
Biomolecules & Therapeutics
;
: 44-56, 2017.
Artículo
en Inglés
| WPRIM
| ID: wpr-165939
ABSTRACT
Insulin resistance is characterized by the reduced ability of insulin to stimulate tissue uptake and disposal of glucose including cardiac muscle. These conditions accelerate the progression of heart failure and increase cardiovascular morbidity and mortality in patients with cardiovascular diseases. It is noteworthy that some conditions of insulin resistance are characterized by up-regulation of the sympathetic nervous system, resulting in enhanced stimulation of β-adrenergic receptor (βAR). Over-stimulation of βARs leads to the development of heart failure and is associated with the pathogenesis of insulin resistance in the heart. However, pathological consequences of the cross-talk between the βAR and the insulin sensitivity and the mechanism by which βAR over-stimulation promotes insulin resistance remain unclear. This review article examines the hypothesis that βARs over-stimulation leads to induction of insulin resistance in the heart.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Sistema Nervioso Simpático
/
Resistencia a la Insulina
/
Enfermedades Cardiovasculares
/
Regulación hacia Arriba
/
Mortalidad
/
Proteínas Quinasas Dependientes de AMP Cíclico
/
Glucosa
/
Corazón
/
Cardiopatías
/
Insuficiencia Cardíaca
Tipo de estudio:
Estudio pronóstico
Límite:
Humanos
Idioma:
Inglés
Revista:
Biomolecules & Therapeutics
Año:
2017
Tipo del documento:
Artículo
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