Chronic Chlamydia pneumoniae Infection as a Risk Factor for Acute Myocardial Infarction in Korea
Korean Circulation Journal
;
: 407-415, 2000.
Artículo
en Coreano
| WPRIM
| ID: wpr-166256
ABSTRACT
BACKGROUND AND OBJECTIVES:
To evaluate the association between chronic infection with Chlamydia pneumoniae, as measured by Immunoglobulin G and A, and acute myocardial infarction (AMI) in Korea. MATERIALS ANDMETHODS:
A total of 136 patients [normal control 65 cases (malefemale 278, mean age 55.1+/-11.7 years), AMI 71 cases (malefemale 5417, mean age 58.9+/-12.7 years)] had immunoglobulin G, A, and M antibody titers measured against Chlamydia pneumoniae by microimmunoflorescence assay and had coronary angiography performed. We investigated the incidence of major adverse cardiac events (MACE) at 6 month follow-up. Controls were defined as patients with no significant stenosis on coronary angiography.RESULTS:
1) AMI patients were more likely to be male (76.1 41.5%) and smokers (67.6 16.9%) compared with the controls. >2) In AMI patients, there was a weak correlation with IgG and IgA antibody titers (r=0.39, p=0.001).> 3) After adjusting for gender and smoking status, IgG and IgA antibody titers were similar between two groups.> 4) Increased IgG and IgA titers did not affect the MACE during follow-up.CONCLUSION:
Chronic Chlamydia pneumoniae infection detected by immunoglobulin assay is not significantly associated with AMI. Further studies, such as polymerase chain reaction, immunocytochemistry, or culture of the atheromatous plaques, are needed to better define the association.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Humo
/
Inmunoglobulina A
/
Inmunoglobulina G
/
Inmunoglobulinas
/
Inmunohistoquímica
/
Fumar
/
Chlamydia
/
Reacción en Cadena de la Polimerasa
/
Incidencia
/
Factores de Riesgo
Tipo de estudio:
Estudio de etiología
/
Estudio de incidencia
/
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Humanos
/
Masculino
País/Región como asunto:
Asia
Idioma:
Coreano
Revista:
Korean Circulation Journal
Año:
2000
Tipo del documento:
Artículo
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