Glycoproteomic analysis of plasma from patients with atopic dermatitis: CD5L and ApoE as potential biomarkers
Experimental & Molecular Medicine
;
: 677-685, 2008.
Artículo
en Inglés
| WPRIM
| ID: wpr-167145
ABSTRACT
Atopic dermatitis (AD) is an inflammatory skin disorder that is both uncomfortable and distressing to patients, and its prevalence has been steadily increasing. It is obvious that the identification of efficient markers of AD in plasma would offer the possibility of effective diagnosis, prevention, and treatment strategies. In this study, a proteomic approach was used to analyze plasma glycoproteins from both children with AD and healthy child donors. Several protein spots showing significant quantitative changes in the AD patients were identified. Through sequential studies, it was confirmed that CD5L and ApoE were significantly up-regulated or down-regulated, respectively, in the plasma from AD patients compared with that from healthy donors. In addition, we suggest that the up-regulated CD5L in AD patients causes eosinophilia by inhibiting apoptosis or promoting the proliferation of eosinophils either in combination with or without IL-5. The glycoproteomic data in this study provides clues to understanding the mechanism of atopic alterations in plasma and suggests AD-related proteins can be used as candidate markers for AD.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Apolipoproteínas E
/
Glicoproteínas
/
Biomarcadores
/
Línea Celular
/
Interleucina-5
/
Proteómica
/
Proliferación Celular
/
Dermatitis Atópica
/
Eosinofilia
/
Eosinófilos
Tipo de estudio:
Estudio pronóstico
Límite:
Niño
/
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Experimental & Molecular Medicine
Año:
2008
Tipo del documento:
Artículo
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