A Case of Solitary Malignant Peripheral Nerve Sheath Tumor on a Finger / 대한피부과학회지

ABSTRACT

The malignant peripheral nerve sheath tumor is a rare neoplasm arising from the neural sheath of peripheral nerve sheath, accounting for less than 5% of all soft tissue malignancy. Most tumors occur in patients with neurofibromatosis and solitary malignant peripheral nerve sheath tumor without neurofibromatosis is rare. A review of the literature revealed that there were relatively few documeted cases of these tumors involving digits, although there were several cases of these tumors involving the major peripheral nerve trunk. We report a case of solitary malignant peripheral nerve sheath tumor on a finger, which neither originated from the major peripheral nerve nor was associated with neurofibromatosis. A 46-year-old woman showed a solitary, child palm-sized, eroded fungating tumor on her right third finger tip. Immunohistochemical studies for S-100, neuron-specific enolase, vimentin and electron microscopy were used in the diagnosis, confirming the neural origin of this tumor.