Fixation of Properdin and Factor B by Bullous Pemphigoid Antibody (in vitro Study) / 대한피부과학회지
Korean Journal of Dermatology
;
: 81-86, 1980.
Artículo
en Inglés
| WPRIM
| ID: wpr-16761
ABSTRACT
Ten serum samples from the patient with bullous pemphigoid with the baseruent mernbrane zone autoantibody titers of 320 or greater were tested, by the method of in vitro complement immunofluorescence, for their ability to fix Factor B and properdin in addition to Clq, C4 and C3. Five samples yielded positive C3 and properdin staining reaciions while four samples demonstrated positive Factor B stainings. All ten samples yieled positive C3, C4 and Clq staining reactions, Heat inactivation or treatment of the complement source with EDTA, MG2-EGTA abolished both C3, properdin and Factor B staining in all ten cases. This result suggest that pemphigoid antibody will fix properdin and Factor B in addition to Clq, C4 and C3, a phenomenon explained by assembly of the C3b amplification mechanism following activation of the classical pathway of complement system.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Proteínas del Sistema Complemento
/
Properdina
/
Factor B del Complemento
/
Técnica del Anticuerpo Fluorescente
/
Penfigoide Ampolloso
/
Ácido Edético
/
Calor
Límite:
Humanos
Idioma:
Inglés
Revista:
Korean Journal of Dermatology
Año:
1980
Tipo del documento:
Artículo
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