The Relationship Between Ascorbic Acid Concentration of Anterior Chamber and Complication in Alkali-Injured Rabbit Eyes
Journal of the Korean Ophthalmological Society
;
: 2065-2070, 2005.
Artículo
en Coreano
| WPRIM
| ID: wpr-167845
ABSTRACT
PURPOSE:
To study the relationship between the concentration of ascorbic acid in the anterior chamber and the complications of an experimental alkali burn in rabbit corneas.METHODS:
Standardized corneal alkali wounds were induced in both eyes of 33 albino rabbits by applying a 5.5 mm-sized round filter paper, soaked in 1N NaOH for 20 seconds. Then, the control group (22 eyes) was given Tears Natural II(R) (Alcon), treated group A (22 eyes) was given ascorbic acid (10%) for 2 hours, and treated group B (22 eyes) was given ascorbic acid (10%) for 6 hours. The concentrations of ascorbic acid in the anterior chamber were measured using a microplate assay immediately post-injury, and at 5 days, 15 days, and 30 days post-injury. During the experiment, clinical observation was performed to detect complications such as corneal ulcer or perforation.RESULTS:
The incidence of ulceration was significantly lower between control group and treated groups A and B (p<0.05). The incidence of perforation was significantly lower in treated group A compared to the control group B (p<0.05). In addition, a higher concentration of ascorbic acid in the anterior chamber and a lower severity of corneal injury was significant (sigma=-0.302, P<0.05).CONCLUSIONS:
Higher concentrations of ascorbic acid in the anterior chamber were associated with fewer complications in experimental alkali burns in rabbit corneas.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Ácido Ascórbico
/
Úlcera
/
Heridas y Lesiones
/
Quemaduras
/
Úlcera de la Córnea
/
Incidencia
/
Córnea
/
Álcalis
/
Cámara Anterior
Tipo de estudio:
Estudio de incidencia
/
Estudio pronóstico
Límite:
Animales
Idioma:
Coreano
Revista:
Journal of the Korean Ophthalmological Society
Año:
2005
Tipo del documento:
Artículo
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