Modulatory Effect of Ammonium Carbonate on the GABAA Receptor / 대한소아신경학회지
Journal of the Korean Child Neurology Society
;
(4): 39-46, 1998.
Artículo
en Coreano
| WPRIM
| ID: wpr-16810
ABSTRACT
PURPOSE:
This study was aimed to investigate the modulatory effect of ammonium carbonate on the GABAA receptor.METHODS:
The effects of ammonium carbonate on the binding of radioligands to components of the GABAA receptor complex were observed.RESULTS:
[3H]Flunitrazepam binding to the benzodiazepine receptor was enhanced by ammonium (1mM) ammonia concentrations. This increase in GABAergic neurotransmission is consistent with the clinical picture of lethargy, ataxia and cognitive deficits associated with liver failure and congenital hyperammonemia.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Ataxia
/
Carbono
/
Fallo Hepático
/
Receptores de GABA
/
Receptores de GABA-A
/
Transmisión Sináptica
/
Hiperamonemia
/
Letargia
/
Compuestos de Amonio
/
Ácido gamma-Aminobutírico
Idioma:
Coreano
Revista:
Journal of the Korean Child Neurology Society
Año:
1998
Tipo del documento:
Artículo
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