Stroke Associated With Protein C and S deficiency in Neonate: Report of two Cases

ABSTRACT

Recently, cases of stroke with inherited disorders of blood coagulation have been reported in children. Deficiency of protein C or S predisposing to a hypercoagulable state has been associated with cerebrovascular disease. We describe here two cases of cerebral infarction in neonates presenting with respiratory distress and seizure respectively. One had decreased protein C and the other was found to have decreased protein C and S. One case had asphyxia as an additional risk factor for stroke. No specific therapy was administered in both cases. They are currently being observed in the outpatient clinic without specific events.