UDP-glucuronosyltransferase 1A1 Gene Polymorphism in Severe Neonatal Hyperbilirubinemia
Journal of the Korean Society of Neonatology
;
: 46-52, 2007.
Artículo
en Coreano
| WPRIM
| ID: wpr-16828
ABSTRACT
PURPOSE:
TATA box mutation/polymorphism in the promoter region of the bilirubin uridinediphosphoglucuronate glucuronosyltransferase 1A1 (UGT-1A1) gene is known to be an etiology of hyperbilirubinemia. This study examined if a TATA box mutation/polymorphism in UGT-1A1 gene promoter could be associated with the development of severe early neonatal jaundice in Korean infants.METHODS:
Thirty-nine neonatal jaundice patients and 40 controlled infants were analyzed for UGT-1A1 promoter genotypes by using DNA sequencing.RESULTS:
The homozygote for (TA)7TAA mutation was not found in this study. Comparison of the prevalence of UGT-1A1 promoter (TA)7TAA heterozygotes revealed no difference between the group with jaundice and the controlled group (15.4% vs. 10%). The peak bilirubin level was higher and the onset of jaundice was earlier in the jaundice group with (TA)7TAA heterozygote compared to the jaundice group without (TA)7TAA heterozygote (23.2+/-1.0 mg/dL vs. 19.7+/-2.4 mg/dL, P=0.004, 5.0+/-1.5 days vs. 8.3+/-4.1 days, P= 0.057).CONCLUSION:
The results of this study showed that TATA box polymorphism in UGT-1A1 gene promoter did not increase the prevalence of severe early neonatal jaundice in Korean infants.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Bilirrubina
/
Prevalencia
/
TATA Box
/
Regiones Promotoras Genéticas
/
Glucuronosiltransferasa
/
Análisis de Secuencia de ADN
/
Hiperbilirrubinemia Neonatal
/
Genotipo
/
Heterocigoto
/
Homocigoto
Tipo de estudio:
Estudio de prevalencia
Límite:
Humanos
/
Lactante
/
Recién Nacido
Idioma:
Coreano
Revista:
Journal of the Korean Society of Neonatology
Año:
2007
Tipo del documento:
Artículo
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