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PAUF promotes adhesiveness of pancreatic cancer cells by modulating focal adhesion kinase
Experimental & Molecular Medicine ; : 291-297, 2011.
Artículo en Inglés | WPRIM | ID: wpr-168748
ABSTRACT
Pancreatic cancer is a notorious disease with a poor prognosis and low survival rates, which is due to limited advances in understanding of the molecular mechanism and inadequate development of effective treatment options over the decades. In previous studies, we demonstrated that a novel soluble protein named pancreatic adenocarcinoma up-regulated factor (PAUF) acts on tumor and immune cells and plays an important role in metastasis and progression of pancreatic cancer. Here we show that PAUF promotes adhesiveness of pancreatic cancer cells to various extracellular matrix (ECM). Our results further support a positive correlation of activation and expression of focal adhesion kinase (FAK), a key player in tumor cell metastasis and survival, with PAUF expression. PAUF-mediated adhesiveness was significantly attenuated upon blockade of the FAK pathway. Moreover, PAUF appeared to enhance resistance of pancreatic cancer cells to anoikis via modulation of FAK. Our results suggest that PAUF-mediated FAK activation plays an important role in pancreatic cancer progression.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Neoplasias Pancreáticas / Transducción de Señal / Proteínas Proto-Oncogénicas pp60(c-src) / Adhesiones Focales / Anoicis / Línea Celular Tumoral / Proteína-Tirosina Quinasas de Adhesión Focal / Lectinas Tipo de estudio: Estudio pronóstico Límite: Humanos Idioma: Inglés Revista: Experimental & Molecular Medicine Año: 2011 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Neoplasias Pancreáticas / Transducción de Señal / Proteínas Proto-Oncogénicas pp60(c-src) / Adhesiones Focales / Anoicis / Línea Celular Tumoral / Proteína-Tirosina Quinasas de Adhesión Focal / Lectinas Tipo de estudio: Estudio pronóstico Límite: Humanos Idioma: Inglés Revista: Experimental & Molecular Medicine Año: 2011 Tipo del documento: Artículo