Evaluation of the Genetic Toxicity of Cyclopentane and Ammonium Nitrate: In vitro Mammalian Chromosomal Aberration Assay in Chinese Hamster Ovary Cells
Safety and Health at Work
;
: 17-25, 2011.
Artículo
en Inglés
| WPRIM
| ID: wpr-169143
ABSTRACT
OBJECTIVES:
In this study, the in vitro mammalian chromosomal aberration (CA) assay was conducted to gain additional information concerning the hazards associated with the use of cyclopentane and ammonium nitrate. While these two chemicals had already been tested by many methods, they had not been studied in the CA test.METHODS:
The assay was performed using the ovarian infantile cell (CHO-K1 cell), by the direct method (-S9) and by the metabolic activated method (+S9 mix).RESULTS:
Using the direct method, the 7 dosages in a 48 hour treatment group did not show that the frequency of CA is proportion to the dosage addition. The frequency of CA is not proportion to the dosage addition for a 6 hour treatment using the metabolic activated method.CONCLUSION:
From these findings, it was decided that the 2 chemicals do not induce chromosomal aberrations under the tested conditions.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Ovario
/
Aberraciones Cromosómicas
/
Cricetulus
/
Ciclopentanos
/
Pueblo Asiatico
/
Compuestos de Amonio Cuaternario
/
Nitratos
Límite:
Animales
/
Femenino
/
Humanos
Idioma:
Inglés
Revista:
Safety and Health at Work
Año:
2011
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS