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Whole Brain Voxel-Wise Analysis of Cerebral Retention of Beta-Amyloid in Cognitively Normal Older Adults Using ¹⁸F-Florbetaben
Psychiatry Investigation ; : 883-886, 2017.
Artículo en Inglés | WPRIM | ID: wpr-16970
ABSTRACT

OBJECTIVE:

Recently developed 18F-labelled amyloid beta (Aβ) positron emission tomography (PET) tracers have demonstrated potentials to enable more prevalent application of amyloid imaging in the clinical setting. The aim of this study is to demonstrate cerebral retention of Aβ in cognitively normal older adults, by implementing voxel-based analysis on images acquired from 18F-Florbetaben amyloid PET.

METHODS:

Fifty cognitive normal elderly subjects were recruited and included in the study. Demographic data and cognitive measurements were collected. Magnetic resonance imaging (MRI) and ¹⁸F-Florbetaben PET data were obtained followed by whole brain voxel-based analysis.

RESULTS:

Compared to the florbetaben (FBB) (−) counterpart, FBB (+) showed significantly higher Aβ deposition in the brain regions comprising anterior cingulate, middle cingulate, posterior cingulate and precuneus (family wise error corrected p < 0.05). There was no significant correlation between amyloid retention and cognitive functions.

CONCLUSION:

Our results confirms previous results regarding Aβ deposition by using ¹⁸F-Florbetaben, demonstrating potentials in application of 18F-Florbetaben PET imaging in clinical settings.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Lóbulo Parietal / Encéfalo / Imagen por Resonancia Magnética / Cognición / Tomografía de Emisión de Positrones / Enfermedad de Alzheimer / Giro del Cíngulo / Amiloide Límite: Adulto / Anciano / Humanos Idioma: Inglés Revista: Psychiatry Investigation Año: 2017 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Lóbulo Parietal / Encéfalo / Imagen por Resonancia Magnética / Cognición / Tomografía de Emisión de Positrones / Enfermedad de Alzheimer / Giro del Cíngulo / Amiloide Límite: Adulto / Anciano / Humanos Idioma: Inglés Revista: Psychiatry Investigation Año: 2017 Tipo del documento: Artículo