The Role of PKMzeta in Drug Reward Memory / 대한정신약물학회지
Korean Journal of Psychopharmacology
;
: 83-87, 2012.
Artículo
en Coreano
| WPRIM
| ID: wpr-169897
ABSTRACT
Drug addiction is a chronic brain disease with a high incidence of relapse. Environmental cues that previously and repeatedly associated with drugs of abuse easily evoke relapse to addicts even after long period of drug-free state. Such a long lasting property of conditioning is considered a form of long-term memory and has a strong correlation with synaptic plasticity like long-term potentiation (LTP). Protein kinase M zeta (PKMzeta) has been known to play an important role in the maintenance of long-term memory as well as LTP in various brain areas. Likewise, in a few brain areas examined out of the rewarding circuit, PKMzeta seems to play a similarly important role in the maintenance of conditioned memory. These results suggest that PKMzeta may become a new target to manipulate to reverse pre-formed drug-related memory and accompanied behaviors.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Piperazinas
/
Plásticos
/
Recurrencia
/
Recompensa
/
Encéfalo
/
Encefalopatías
/
Proteína Quinasa C
/
Drogas Ilícitas
/
Incidencia
/
Potenciación a Largo Plazo
Tipo de estudio:
Estudio de incidencia
/
Estudio pronóstico
Idioma:
Coreano
Revista:
Korean Journal of Psychopharmacology
Año:
2012
Tipo del documento:
Artículo
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