Nidogen Plays a Role in the Regenerative Axon Growth of Adult Sensory Neurons Through Schwann Cells
Journal of Korean Medical Science
;
: 654-659, 2009.
Artículo
en Inglés
| WPRIM
| ID: wpr-170156
ABSTRACT
We previously reported that nidogen is an extracellular matrix protein regulating Schwann cell proliferation and migration. Since Schwann cells play a critical role in peripheral nerve regeneration, nidogen may play a role in it via regulation of Schwann cells. Here, we demonstrate direct evidence that nidogen induces elongation of regenerative axon growth of adult sensory neurons, and that the effect is Schwann cell dependent. Continuous infusion of recombinant ectodomain of tumor endothelial marker 7, which specifically blocks nidogen function in Schwann cells, suppressed regenerative neurite growth in a sciatic nerve axotomy model. Taken together, it is likely that nidogen is required for proper regeneration of peripheral nerves after injury.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Células Receptoras Sensoriales
/
Células de Schwann
/
Proteínas Recombinantes
/
Glicoproteínas de Membrana
/
Movimiento Celular
/
Neuritas
/
Ratas Sprague-Dawley
/
Axotomía
/
Proliferación Celular
/
Proteínas de la Membrana
Límite:
Animales
Idioma:
Inglés
Revista:
Journal of Korean Medical Science
Año:
2009
Tipo del documento:
Artículo
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