Epigenetic Regulation of Cytokine Gene Expression in T Lymphocytes
Yonsei Medical Journal
;
: 322-330, 2009.
Artículo
en Inglés
| WPRIM
| ID: wpr-170640
ABSTRACT
The developmental program of T helper and regulatory T cell lineage commitment is governed by both genetic and epigenetic mechanisms. The principal events, signaling pathways and the lineage determining factors involved have been extensively studied in the past ten years. Recent studies have elucidated the important role of chromatin remodeling and epigenetic changes for proper regulation of gene expression of lineage-specific cytokines. These include DNA methylation and histone modifications in epigenomic reprogramming during T helper cell development and effector T cell functions. This review discusses the basic epigenetic mechanisms and the role of transcription factors for the differential cytokine gene regulation in the T helper lymphocyte subsets.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Linfocitos T
/
Regulación de la Expresión Génica
/
Citocinas
/
Epigénesis Genética
Límite:
Animales
/
Humanos
Idioma:
Inglés
Revista:
Yonsei Medical Journal
Año:
2009
Tipo del documento:
Artículo
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