Generation and Characterization of Alloenic Radiation Bone Marrow Chimera / 대한면역학회지
Korean Journal of Immunology
;
: 333-341, 1998.
Artículo
en Coreano
| WPRIM
| ID: wpr-171537
ABSTRACT
Allogenic bone marrow chimera has been used to study the differentiation of donor-derived bone marrow cells under the recipient thymic environment, tolerance generaion between recipient and donor cells. We prepared H-2' to H-2 allogenic chimera by transfering bone marrow cells from H-2dmice to r-irradiated H-2k mice, and examined the differentiation ofthe bone marrow cells under allogenic environment. Complete reconstitution with H-2d+ phenotype cells in the thymus of the chimera mice was observed. However, the number of CD4- CD8+ cells dramatically decreased under the recipient thymic environment, CD8+ cells significantly reduced also in spleen and lymph node, compared with that of normal mice. Interestingly, we also observed coexistence of donor-derived cells (H-2k) and recipient derived cells (H-2d) in lymph node and spleen in the chimera. These results suggested that the decrease of CD4-CD8+ cells could be caused by r-irradiation by affecting the recipient thymic environment, and that in this chimera, tolerance between donor-derived cells and recipient-derived cells was maintained.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Fenotipo
/
Bazo
/
Timo
/
Donantes de Tejidos
/
Médula Ósea
/
Células de la Médula Ósea
/
Quimera
/
Ganglios Linfáticos
Límite:
Animales
/
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Immunology
Año:
1998
Tipo del documento:
Artículo
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