Expression of Epidermal c-Kit+ of Vitiligo Lesions Is Related to Responses to Excimer Laser
Annals of Dermatology
; : 457-463, 2016.
Article
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| WPRIM
| ID: wpr-171608
Biblioteca responsable:
WPRO
ABSTRACT
BACKGROUND: The survival and growth of melanocytes are controlled by the binding of stem cell factor to its cell surface receptor c-kit+ (CD117). We have observed that c-kit+ melanocytes existed in some lesions of vitiligo, while Melan A+ cells were absent. OBJECTIVE: To verify possible relation between c-kit+ expression and treatment response in non-segmental vitiligo lesions. METHODS: Skin biopsies were done from the center of the 47 lesions from the 47 patients with non-segmental vitiligo. Expression of c-kit+ and Melan A, and amounts of melanin in the epidermis were assessed in each lesion, and treatment responses to excimer laser were evaluated. RESULTS: Thirty-five of the 47 lesions (74.5%) had c-kit+ phenotypes. There was significant difference of c-kit staining value between good responders in 3 months of excimer laser treatment (average of 24 sessions) and the others. CONCLUSION: c-Kit expression in vitiliginous epidermis may be related to better treatment responses to excimer laser.
Palabras clave
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Fenotipo
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Piel
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Vitíligo
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Biopsia
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Factor de Células Madre
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Proteínas Proto-Oncogénicas c-kit
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Epidermis
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Láseres de Excímeros
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Antígeno MART-1
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Melaninas
Límite:
Humans
Idioma:
En
Revista:
Annals of Dermatology
Año:
2016
Tipo del documento:
Article