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Serologic heterogeneity of HLA-A24 correlates with allelic types in the Korean population
Journal of Korean Medical Science ; : 623-626, 2000.
Artículo en Inglés | WPRIM | ID: wpr-171778
ABSTRACT
HLA-A24 is the second most frequently expressed HLA-A type in Koreans (GF 22.8%). Four different serologic reaction patterns were observed in Korean A24 positive samples using a commercial serologic typing kit. To clarify the nature of serologic heterogeneity, thirteen A24 positive DNA samples representing the four different serologic reaction patterns were subjected to DNA sequencing analysis of the amplified HLA-A genes from each sample. Four A*24 alleles (A*2402101, A*2403, A*2408, and A*2421) were associated with the four unique serologic reaction patterns. During this study, a novel allele, A*2421, was characterized. The new sequence is similar to A*2402101, differing at codon 127 (AAA-->AAC; K-->N). By comparing putative amino acid sequences and serologic reaction patterns of A*24 allelic products identified in this study, several crucial sites for A24- and A9-specific antibody binding were predicted 127K for A24 antibody binding, and 62E-65G and 166D-167G for A9 antibody binding. This information will be helpful for accurately assigning HLA-A24 types by serology and for predicting serologic types of new alleles.
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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Linaje / Sitios de Unión de Anticuerpos / Datos de Secuencia Molecular / Secuencia de Bases / Antígenos HLA-A / ADN Complementario / Heterogeneidad Genética / Alelos / Corea (Geográfico) Tipo de estudio: Estudio pronóstico Límite: Femenino / Humanos / Masculino País/Región como asunto: Asia Idioma: Inglés Revista: Journal of Korean Medical Science Año: 2000 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Linaje / Sitios de Unión de Anticuerpos / Datos de Secuencia Molecular / Secuencia de Bases / Antígenos HLA-A / ADN Complementario / Heterogeneidad Genética / Alelos / Corea (Geográfico) Tipo de estudio: Estudio pronóstico Límite: Femenino / Humanos / Masculino País/Región como asunto: Asia Idioma: Inglés Revista: Journal of Korean Medical Science Año: 2000 Tipo del documento: Artículo