The Study on the Expression of ICAM-1 in Transitional Cell Carcinoma of Bladder / 대한비뇨기과학회지
Korean Journal of Urology
;
: 187-192, 1999.
Artículo
en Coreano
| WPRIM
| ID: wpr-171951
ABSTRACT
PURPOSE:
ICAM-1(Intercellular Adhesion Molecule-1) is a cell adhesion molecule which facilitates the binding of LAK(Lymphokine Activated Killer )cell and cytotoxic T cell to tumor cell. This study investigates the role of ICAM-1 in transitional cell carcinoma(TCC) of bladder. MATERIALS ANDMETHODS:
Immunohistochemical stain for ICAM-1 was done in 42 paraffin embedded tissue of primary TCC of bladder. And we compared the expression of ICAM-1 and the degree of immune cell infiltration, tumor grade, stage and survival rate of the patients.RESULTS:
Immunohistochemical examination demonstrated expression of ICAM-1 on 17 of 42 bladder TCC but not on five normal transitional cells. The more frequently immune cells infiltrated, the more frequently ICAM-1 was expressed(p=0.018). And ICAM-1 was frequently expressed in higher histopathological grade and higher stage tumors(p=0.035, p=0.002). Survival rate was lower in ICAM-1 expressed tumors than in ICAM-1 non-expressed tumors even though it is insignificant statistically(p=0.11).CONCLUSIONS:
These results suggest that ICAM-1 plays an important role on immune therapy for bladder TCC, and ICAM-1 expression in bladder TCC could be another prognostic factor and used as a response predictor for immune therapy such as intravesical BCG instillation.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Parafina
/
Vejiga Urinaria
/
Carcinoma de Células Transicionales
/
Adhesión Celular
/
Tasa de Supervivencia
/
Molécula 1 de Adhesión Intercelular
/
Mycobacterium bovis
Tipo de estudio:
Estudio pronóstico
Límite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Urology
Año:
1999
Tipo del documento:
Artículo
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