Imatinib Plasma Monitoring-Guided Dose Modification for Managing Imatinib-Related Toxicities in Gastrointestinal Stromal Tumor Patients
Journal of Korean Medical Science
; : 1248-1252, 2013.
Article
en En
| WPRIM
| ID: wpr-173127
Biblioteca responsable:
WPRO
ABSTRACT
Imatinib, the first-line treatment in patients with advanced gastrointestinal stromal tumors (GIST), is generally well tolerated, although some patients have difficulty tolerating the standard dose of 400 mg/day. Adjusting imatinib dosage by plasma level monitoring may facilitate management of patients who experience intolerable toxicities due to overexposure to the drug. We present two cases of advanced GIST patients in whom we managed imatinib-related toxicities through dose modifications guided by imatinib plasma level monitoring. Imatinib blood level testing may be a promising approach for fine-tuning imatinib dosage for better tolerability and optimal clinical outcomes in patients with advanced GIST.
Palabras clave
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Piperazinas
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Pirimidinas
/
Benzamidas
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Tomografía Computarizada por Rayos X
/
Exones
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Monitoreo de Drogas
/
Proteínas Proto-Oncogénicas c-kit
/
Tumores del Estroma Gastrointestinal
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Tomografía de Emisión de Positrones
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Neoplasias Gastrointestinales
Límite:
Aged
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Humans
/
Male
Idioma:
En
Revista:
Journal of Korean Medical Science
Año:
2013
Tipo del documento:
Article