The dose effect of ephedrine on the onset time and intubating conditions after cisatracurium administration / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 26-31, 2014.
Artículo
en Inglés
| WPRIM
| ID: wpr-173270
ABSTRACT
BACKGROUND:
The aim of this randomized, double-blind, placebo-controlled study was to evaluate dose effects of ephedrine pretreatment on the onset time and intubating conditions after cisatracurium administration.METHODS:
A total of 140 adult patients were randomized into 4 groups to receive either 30 microg/kg ephedrine (Group 30, n = 35), 70 microg/kg ephedrine (Group 70, n = 35), 110 microg/kg ephedrine (Group 110, n = 35), 3 ml normal saline (Group C, n = 35) as pretreatment given 30 s before anesthetic induction. Neuromuscular block was achieved with 0.15 mg/kg cisatracurium, evaluated accelomyographically with train-of-four stimulation. An anesthesiologist blinded to patient grouping assessed the intubating conditions 1.5 min after cisatracurium administration.RESULTS:
An onset time of 70 s was obtained in the ephedrine groups (Group 30 155.4 +/- 44.7 s, Group 70 152.6 +/- 40.3 s, Group 110 151.2 +/- 51.6 s) compared to Group C (224.6 +/- 56.9 s) after 0.15 mg/kg of cisatracurium (P 200/100 mmHg) 1 min after tracheal intubation with no patients in other groups.CONCLUSIONS:
We conclude that pre-treatment with ephedrine 70 microg/kg improved intubating conditions 1.5 min after cisatracurium administration and facilitated the onset of neuromuscular block (70 s) without adverse hemodynamic effects.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Presión Sanguínea
/
Bloqueo Neuromuscular
/
Efedrina
/
Frecuencia Cardíaca
/
Hemodinámica
/
Hipertensión
/
Intubación
Tipo de estudio:
Ensayo Clínico Controlado
Límite:
Adulto
/
Humanos
Idioma:
Inglés
Revista:
Korean Journal of Anesthesiology
Año:
2014
Tipo del documento:
Artículo
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