Your browser doesn't support javascript.
loading
Role of KCa Channels in SNAP-Induced Relaxation of Aorta from Renal Hypertensive Rats / 대한신장학회지
Korean Journal of Nephrology ; : 398-403, 2007.
Artículo en Coreano | WPRIM | ID: wpr-173290
ABSTRACT

PURPOSE:

S-nitroso-N-acetylpenicillamine (SNAP), a nitric oxide (NO) donor, is thought to relax vascular smooth muscle by stimulation of soluble guanylate cyclase, accumulation of its product cyclic GMP (cGMP) level. Evidence has emerged that NO-induced vasodilatation is also mediated by stimulating Ca2+-activated K+ (KCa) channels directly or indirectly through cGMP. The aim of the present study was to investigate possible involvement or alteration of KCa channels in the mechanism of vasodilation induced by SNAP in two-kidney, one-clip (2K1C) hypertensive rats.

METHODS:

2K1C hypertension was made by clipping the left renal artery and age-matched control rats received a sham treatment. Using rings prepared from thoracic aortae, we studied changes in isometric tension of the rings in response to SNAP to evaluate effects of a soluble guanylate cyclase inhibitor methylene blue (MB), and a specific blocker of KCa channel iberiotoxin (ITX).

RESULTS:

Aortic rings from 2K1C hypertensive and sham-clipped control rats precontracted with phenylephrine showed similar relaxation to SNAP. MB markedly suppressed the SNAP-induced relaxation in both groups, leaving about 30% of MB-resistant relaxation. ITX nearly completely eliminated the MB-resistant relaxation in control rats, but it did not affect 2K1C rats.

CONCLUSION:

These results suggest that SNAP-induced vasorelaxation is mediated through cGMP- dependent and cGMP-independent KCa channel involving mechanisms, the latter may be altered in 2K1C renal hypertension.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Aorta / Aorta Torácica / Fenilefrina / Placebos / Relajación / Arteria Renal / Donantes de Tejidos / Vasodilatación / GMP Cíclico / S-Nitroso-N-Acetilpenicilamina Tipo de estudio: Ensayo Clínico Controlado Límite: Animales / Humanos Idioma: Coreano Revista: Korean Journal of Nephrology Año: 2007 Tipo del documento: Artículo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Aorta / Aorta Torácica / Fenilefrina / Placebos / Relajación / Arteria Renal / Donantes de Tejidos / Vasodilatación / GMP Cíclico / S-Nitroso-N-Acetilpenicilamina Tipo de estudio: Ensayo Clínico Controlado Límite: Animales / Humanos Idioma: Coreano Revista: Korean Journal of Nephrology Año: 2007 Tipo del documento: Artículo