Protective Effect of HP08-0106 on Ligature-induced Periodontitis in Rats
International Journal of Oral Biology
;
: 187-194, 2011.
Artículo
en Coreano
| WPRIM
| ID: wpr-173972
ABSTRACT
Periodontitis is an inflammatory disorder of the periodontium, characterized by destruction of the tooth supporting tissues including alveolar bone and mediated by various pro-inflammatory mediators. Here, we demonstrated that HP08-0106, composed of four crude drugs-Gardenia jasminoides Grandiflora, Angelica gigas Nakai, Rehmannia glutinosa, and Schizonepeta tenuifolia in a weight ratio of 2212, perturbs inflammatory responses, osteoclast formation in LPS-induced RAW 264.7 cells and alveolar bone resorption in ligature-induced periodontitis. HP08-0106 decreased the protein level of iNOS and COX2 as well as the secreted level of IL-1beta, indicating that HP08-0106 has antiinflammatory effects. HP08-0106 also inhibited the expression of genes associated with osteoclastogenesis including c-Fos, MMP-9 and TRAP. Moreover, HP08-0106 exhibited a protective effect from alveolar bone loss in ligature-induced periodontitis animal models. Our results strongly suggest that HP08-0106 represent an important therapeutic tool to treat inflammatory disorders associated with bone loss such as periodontitis.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Osteoclastos
/
Periodontitis
/
Diente
/
Resorción Ósea
/
Periodoncio
/
Pérdida de Hueso Alveolar
/
Lamiaceae
/
Modelos Animales
/
Angelica
/
Rehmannia
Límite:
Animales
Idioma:
Coreano
Revista:
International Journal of Oral Biology
Año:
2011
Tipo del documento:
Artículo
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