Protective Effect of HP08-0106 on Ligature-induced Periodontitis in Rats
International Journal of Oral Biology
; : 187-194, 2011.
Article
en Ko
| WPRIM
| ID: wpr-173972
Biblioteca responsable:
WPRO
ABSTRACT
Periodontitis is an inflammatory disorder of the periodontium, characterized by destruction of the tooth supporting tissues including alveolar bone and mediated by various pro-inflammatory mediators. Here, we demonstrated that HP08-0106, composed of four crude drugs-Gardenia jasminoides Grandiflora, Angelica gigas Nakai, Rehmannia glutinosa, and Schizonepeta tenuifolia in a weight ratio of 2212, perturbs inflammatory responses, osteoclast formation in LPS-induced RAW 264.7 cells and alveolar bone resorption in ligature-induced periodontitis. HP08-0106 decreased the protein level of iNOS and COX2 as well as the secreted level of IL-1beta, indicating that HP08-0106 has antiinflammatory effects. HP08-0106 also inhibited the expression of genes associated with osteoclastogenesis including c-Fos, MMP-9 and TRAP. Moreover, HP08-0106 exhibited a protective effect from alveolar bone loss in ligature-induced periodontitis animal models. Our results strongly suggest that HP08-0106 represent an important therapeutic tool to treat inflammatory disorders associated with bone loss such as periodontitis.
Palabras clave
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Osteoclastos
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Periodontitis
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Diente
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Resorción Ósea
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Periodoncio
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Pérdida de Hueso Alveolar
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Lamiaceae
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Modelos Animales
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Angelica
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Rehmannia
Límite:
Animals
Idioma:
Ko
Revista:
International Journal of Oral Biology
Año:
2011
Tipo del documento:
Article