The relationship between muscle mitochondrial nutritional overloading and insulin resistance / 영남의대학술지
Yeungnam University Journal of Medicine
;
: 19-28, 2017.
Artículo
en Inglés
| WPRIM
| ID: wpr-174152
ABSTRACT
The incidence of type 2 diabetes mellitus and insulin resistance is growing rapidly. Multiple organs including the liver, skeletal muscle and adipose tissue control insulin sensitivity coordinately, but the mechanism of skeletal muscle insulin resistance has not yet been fully elucidated. However, there is a growing body of evidence that lipotoxicity induced by mitochondrial dysfunction in skeletal muscle is an important mediator of insulin resistance. However, some recent findings suggest that skeletal mitochondrial dysfunction generated by genetic manipulation is not always correlated with insulin resistance in animal models. A high fat diet can provoke insulin resistance despite a coordinate increase in skeletal muscle mitochondria, which implies that mitochondrial dysfunction is not mandatory in insulin resistance. Furthermore, incomplete fatty acid oxidation by excessive nutrition supply compared to mitochondrial demand can induce insulin resistance without preceding impairment of mitochondrial function. Taken together we suggested that skeletal muscle mitochondrial overloading, not mitochondrial dysfunction, plays a pivotal role in insulin resistance.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Resistencia a la Insulina
/
Tejido Adiposo
/
Incidencia
/
Especies Reactivas de Oxígeno
/
Músculo Esquelético
/
Modelos Animales
/
Diabetes Mellitus Tipo 2
/
Dieta Alta en Grasa
/
Insulina
/
Hígado
Tipo de estudio:
Estudio de incidencia
/
Estudio pronóstico
Idioma:
Inglés
Revista:
Yeungnam University Journal of Medicine
Año:
2017
Tipo del documento:
Artículo
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