Serum amyloid A inhibits dendritic cell differentiation by suppressing GM-CSF receptor expression and signaling
Experimental & Molecular Medicine
; : e369-2017.
Article
en En
| WPRIM
| ID: wpr-174863
Biblioteca responsable:
WPRO
ABSTRACT
In this study, we report that an acute phase reactant, serum amyloid A (SAA), strongly inhibits dendritic cell differentiation induced by GM-CSF plus IL-4. SAA markedly decreased the expression of MHCII and CD11c. Moreover, SAA decreased cell surface GM-CSF receptor expression. SAA also decreased the expression of PU.1 and C/EBPα, which play roles in the expression of GM-CSF receptor. This inhibitory response by SAA is partly mediated by the well-known SAA receptors, Toll-like receptor 2 and formyl peptide receptor 2. Taken together, we suggest a novel insight into the inhibitory role of SAA in dendritic cell differentiation.
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Índice:
WPRIM
Asunto principal:
Células Dendríticas
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Proteína Amiloide A Sérica
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Factor Estimulante de Colonias de Granulocitos y Macrófagos
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Interleucina-4
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Receptores de Factor Estimulante de Colonias de Granulocitos y Macrófagos
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Receptores de Formil Péptido
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Receptores Toll-Like
Idioma:
En
Revista:
Experimental & Molecular Medicine
Año:
2017
Tipo del documento:
Article