Growth Differentiation Factor 15 Expression in Astrocytes After Excitotoxic Lesion in the Mouse Hippocampus
Experimental Neurobiology
;
: 133-138, 2015.
Artículo
en Inglés
| WPRIM
| ID: wpr-175044
ABSTRACT
Growth differentiation factor 15 (GDF15) is, a member of the transforming growth factor beta (TGF-beta) superfamily of proteins. Although GDF15 is well established as a potent neurotrophic factor for neurons, little is known about its role in glial cells under neuropathological conditions. We monitored GDF15 expression in astrocyte activation after a kainic acid (KA)-induced neurodegeneration in the ICR mice hippocampus. In control, GDF15 immunoreactivity (IR) was evident in the neuronal layer of the hippocampus; however, GDF15 expression had increased in activated astrocytes throughout the hippocampal region at day 3 after the treatment with KA. LPS treatment in astrocytes dramatically increased GDF15 expression in primary astrocytes. In addition, LPS treatment resulted in the decrease of the IkappaB-alpha degradation and increase of the phosphorylation level of RelA/p65. These results indicate that GDF15 has a potential link to NF-kappaB activation, making GDF15 a valuable target for modulating inflammatory conditions.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Fosforilación
/
Neuroglía
/
Astrocitos
/
FN-kappa B
/
Factor de Crecimiento Transformador beta
/
Factor 15 de Diferenciación de Crecimiento
/
Hipocampo
/
Ácido Kaínico
/
Ratones Endogámicos ICR
/
Neuronas
Límite:
Animales
Idioma:
Inglés
Revista:
Experimental Neurobiology
Año:
2015
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS