Aberrant Thalamocortical Synchrony Associated with Behavioral Manifestations in Git1-/- Mice
Experimental Neurobiology
; : 126-132, 2015.
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| ID: wpr-175045
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ABSTRACT
Cross-talk between the thalamus and cortex has been implicated in attention but its pathogenic role in attention-deficit/hyperactivity disorder (ADHD) remains unknown. Here, I demonstrate that Git1-/- mice, previously proposed as an animal model for ADHD, show abnormal theta oscillation in the thalamus. Multi-electrode recordings revealed that Git1-/- mice have hyper-synchrony of neural activities between the thalamus and cortex. The abnormal thalamic oscillation and thalamocortical synchrony in Git1-/- mice were markedly reduced by amphetamine. In addition, ethosuximide ameliorates abnormal thalamic oscillation and ADHD-like hyperactivity shown in Git1-/- mice. My study suggests critical roles of GIT1 and thalamocortical neural circuitry in ADHD.
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Índice:
WPRIM
Asunto principal:
Tálamo
/
Modelos Animales
/
Etosuximida
/
Anfetamina
Límite:
Animals
Idioma:
En
Revista:
Experimental Neurobiology
Año:
2015
Tipo del documento:
Article