Effect of Gd-DTPA on Diffusion in Canine Brain with Hyperacute Stroke
Journal of the Korean Society of Magnetic Resonance in Medicine
; : 158-165, 2002.
Article
en Ko
| WPRIM
| ID: wpr-175541
Biblioteca responsable:
WPRO
ABSTRACT
PURPOSE: To evaluate the effect of Gd-DTPA on signal intensity of diffusion-weighted magnetic resonance (MR) image and apparent diffuse coefficient (ADC) in dog brain with hyperacute stroke. MATERIALS AND METHODS: Experimental canine model of hyperacute cerebral infarction was made by selective intraarterial embolization with particulate embolic material. Diffusion-weighted MR imaging was performed in five dogs at 1 hour after the embolization of internal carotid artery. After intravenous bolus injection of Gd-DTPA, additional 11 diffusion-weighted MR images were serially obtained from 2 minutes to 90 minutes after injection in each dog. The author evaluated findings of hyperacute cerebral infarction on diffusion-weighted MR imaging, and calculated mean signal intensity and mean ADC in infarcted region and contralateral normal region. Statistical analysis of mean signal intensity, mean ADC and contrast-noise ratio before and after Gd-DTPA injection was performed. RESULTS: Hyperacute cerebral infarction developed in all five dogs on diffusion-weighted MR images obtained 1 hour after embolization. The area of hyperacute infarction had steady increase in signal intensity on diffusion-weighted MR image and decrease in ADC. In normal perfusion area, decrease in signal intensity was observed at 2 minutes the Gd-DTPA injection, whereas ADC did not changed. CONCLUSION: Intravenous injection of Gd-DTPA had no influence on ADC in both hyperacute infarction and normally perfused area, but caused initial transient signal reduction in normally perfused area on diffusion-weighted MR image due to susceptibility effect of Gd-DTPA. It is important to calculate ADC in evaluating the effect of diffusion after injection of Gd-DTPA.
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Índice:
WPRIM
Asunto principal:
Perfusión
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Encéfalo
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Imagen por Resonancia Magnética
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Arteria Carótida Interna
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Infarto Cerebral
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Gadolinio DTPA
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Accidente Cerebrovascular
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Difusión
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Infarto
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Inyecciones Intravenosas
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
Ko
Revista:
Journal of the Korean Society of Magnetic Resonance in Medicine
Año:
2002
Tipo del documento:
Article