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Cortical Neuronal Loss after Chronic Prenatal Hypoxia: A Comparative Laboratory Study
Journal of Korean Neurosurgical Society ; : 488-491, 2014.
Artículo en Inglés | WPRIM | ID: wpr-176256
ABSTRACT

OBJECTIVE:

The purpose of this study was to investigate the prenatal hypoxic effect on the fetal brain development.

METHODS:

We used the guinea pig chronic placental insufficiency model to investigate the effect of hypoxia on fetal brain development. We ligated unilateral uterine artery at 30-32 days of gestation (dg with term defined as -67 dg). At 50 dg, 60 dg, fetuses were sacrificed and assigned to either the growth-restricted (GR) or control (no ligation) group. After fixation, dissection, and sectioning of cerebral tissue from these animals, immunohistochemistry was performed with NeuN antibody, which is a mature neuronal marker in the cerebral cortex.

RESULTS:

The number of NeuN-immunoreactive (IR) cells in the cerebral cortex did not differ between the GR and control groups at 50 dg. However, the number of NeuN-IR cells was lesser in GR fetuses than in controls at 60 dg (p<0.05).

CONCLUSION:

These findings show that chronic prenatal hypoxia affect the number of neuron in the cerebral cortex of guinea pig fetus at 60 dg. The approach used in this study is helpful for extending our understanding of neurogenesis in the cerebral cortex, and the findings may be useful for elucidating the brain injury caused by prenatal hypoxia.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Insuficiencia Placentaria / Encéfalo / Lesiones Encefálicas / Inmunohistoquímica / Corteza Cerebral / Neurogénesis / Arteria Uterina / Feto / Cobayas / Hipoxia Tipo de estudio: Estudio pronóstico Límite: Animales / Embarazo Idioma: Inglés Revista: Journal of Korean Neurosurgical Society Año: 2014 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Insuficiencia Placentaria / Encéfalo / Lesiones Encefálicas / Inmunohistoquímica / Corteza Cerebral / Neurogénesis / Arteria Uterina / Feto / Cobayas / Hipoxia Tipo de estudio: Estudio pronóstico Límite: Animales / Embarazo Idioma: Inglés Revista: Journal of Korean Neurosurgical Society Año: 2014 Tipo del documento: Artículo